| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Cucchiaro, Alexandra M (16)
|
MDGBSA |
2:45.77 |
2:40.26 |
-5.51 |
| 2 |
Briggs, Emily R (16)
|
MDEST |
2:49.44 |
2:47.47 |
-1.97 |
| 3 |
Byers, Hope A (15)
|
MDLBA |
2:50.43 |
2:50.02 |
-0.41 |
| 4 |
Woods, Mary D (17)
|
MDGBSA |
2:55.38 |
2:51.22 |
-4.16 |
| 5 |
Yeagle, Alexis L (17)
|
MDEST |
2:59.36 |
2:58.01 |
-1.35 |
| 6 |
Hines, Nyah E (18)
|
MDEST |
2:54.28 |
2:58.90 |
4.62 |
| 7 |
Hopkins, Delaney B (15)
|
MDBAAC |
3:07.23 |
3:01.24 |
-5.99 |
| 8 |
Nelson, Sarah L (16)
|
MDBAAC |
3:12.04 |
3:05.21 |
-6.83 |
| 9 |
Skvortsova, Margarita (16)
|
MDEST |
2:53.99 |
3:05.33 |
11.34 |
| 10 |
Taylor, Anna E (16)
|
MDBAAC |
3:13.95 |
3:09.41 |
-4.54 |
| 11 |
Muhammad, Ndera S (17)
|
MDBCSC |
3:47.68 |
3:47.62 |
-0.06 |
| 12 |
Fletcher, Brianna L (15)
|
MDFMSC |
4:24.02 |
4:05.83 |
-18.19 |
|
Watson, Lauren S (16)
|
MDMAS |
|
DQ |
- |
|
Semmes-Valcich, Aidan D (15)
|
MDSPY |
|
NS |
- |