| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Aguirre, Madeleine T (14)
|
MASSC |
4:29.92 |
4:43.26 |
13.34 |
| 2 |
Lopez-Ona, Marissa A (13)
|
MAPCAC |
4:52.61 |
4:54.65 |
2.04 |
| 3 |
Lopez-Ona, Gabriella A (13)
|
MAPCAC |
4:55.41 |
5:02.90 |
7.49 |
| 4 |
Roling, Sophie E (14)
|
MAPCAC |
5:00.30 |
5:07.97 |
7.67 |
| 5 |
Myers, Grace (13)
|
MALMAC |
5:12.89 |
5:08.09 |
-4.80 |
| 6 |
Williams, Ainsley C (13)
|
MAPJA |
|
5:11.68 |
- |
| 7 |
Lebed, Michelle (14)
|
MAUN |
5:30.88 |
5:13.27 |
-17.61 |
| 8 |
Shack, Sophie (14)
|
MAFCA |
5:25.49 |
5:18.42 |
-7.07 |
| 9 |
Gutekunst, Jessica M (13)
|
MACBST |
|
5:18.78 |
- |
| 10 |
Volpp, Anna (13)
|
MAFCA |
5:49.56 |
5:24.32 |
-25.24 |
| 11 |
Qin, Michelle M (14)
|
MAFCA |
5:36.41 |
5:30.14 |
-6.27 |
| 12 |
Silbert, Anya M (13)
|
MAFCA |
5:49.99 |
5:40.83 |
-9.16 |
| 13 |
Shende, Ashwini (13)
|
MAFCA |
6:36.51 |
6:05.51 |
-31.00 |
|
Shokoufandeh, Mina M (13)
|
MACBST |
|
DQ |
- |
|
Zlotnikoff, Carly B (14)
|
MACBST |
|
NS |
- |
|
Campbell, Cailin E (14)
|
MAGSY |
5:07.92 |
NS |
- |