| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Brandt, Mackenzie A (15)
|
MASSC |
4:56.23 |
4:33.82 |
-22.41 |
| 2 |
Shifflett, Ella M (15)
|
MASSC |
4:58.51 |
4:51.42 |
-7.09 |
| 3 |
Levensten, Kate E (15)
|
MASSC |
4:53.37 |
4:54.67 |
1.30 |
| 4 |
Kim, Minji (13)
|
MASSC |
5:16.55 |
5:01.35 |
-15.20 |
| 5 |
Cappola, Alexandra G (13)
|
MASSC |
5:13.48 |
5:02.12 |
-11.36 |
| 6 |
Levensten, Sydney J (15)
|
MASSC |
5:11.50 |
5:08.40 |
-3.10 |
| 7 |
Mitchell, Victoria S (14)
|
MASSC |
5:02.00 |
5:09.22 |
7.22 |
| 8 |
Fu, Bernice C (13)
|
MAPWAC |
|
5:16.33 |
- |
| 9 |
Bailey, Skylar J (13)
|
MAMSA |
|
5:18.09 |
- |
| 10 |
Stankiewicz-Goldsmit, Olivi (12)
|
MASSC |
5:57.15 |
5:41.07 |
-16.08 |
| 11 |
Narayanan, Sonia P (13)
|
MAUN |
|
6:32.29 |
- |
|
Daniel, Mary Katherine A (12)
|
MASSC |
|
DQ |
- |
|
Wigginton, Samantha L (11)
|
MAHHAA |
|
NS |
- |
|
Brown, Magnolia K (11)
|
MASSC |
|
NS |
- |
|
McGovern, Emma L (17)
|
MASSC |
5:06.47 |
NS |
- |