| # | Swimmer | Team | Seed | Time | Diff |
| 1 |
Cucchiaro, Alexandra M (16)
|
MDGBSA |
5:11.39 |
5:21.60 |
10.21 |
| 2 |
Arciaga, Savannah J (15)
|
MDGBSA |
5:39.39 |
5:32.96 |
-6.43 |
| 3 |
Gurri, Gabriella M (15)
|
MDGBSA |
5:38.09 |
5:45.23 |
7.14 |
| 4 |
Ekanayake, Samantha K (16)
|
MDEST |
5:33.25 |
5:48.58 |
15.33 |
| 5 |
Mahle, Sophia G (15)
|
MDGBSA |
5:58.92 |
5:50.29 |
-8.63 |
| 6 |
Briggs, Emily R (16)
|
MDEST |
5:56.93 |
5:51.32 |
-5.61 |
| 7 |
Swann, Kylie A (17)
|
MDGBSA |
5:49.33 |
6:01.62 |
12.29 |
| 8 |
Sheridan, Olivia C (15)
|
MDEST |
6:11.13 |
6:04.36 |
-6.77 |
| 9 |
Harris, Madison L (17)
|
MDGBSA |
6:04.05 |
6:04.53 |
0.48 |
| 10 |
Mazur, Karolina T (16)
|
MDEST |
6:14.88 |
6:13.56 |
-1.32 |
| 11 |
Klopouh, Milana S (16)
|
MDEST |
6:09.21 |
6:19.73 |
10.52 |
| 12 |
Skvortsova, Margarita (17)
|
MDEST |
6:13.06 |
6:26.03 |
12.97 |
| 13 |
McNeil, Charlee A (15)
|
MDGBSA |
6:21.31 |
6:44.02 |
22.71 |